Weight loss modest with metformin in obese kids
“When people feel as though they’ve failed, they tend to throw in the towel for good instead of giving their resolution another shot.” Here, four of the nation’s top diet experts reveal common weight loss resolutions that almost always backfire. 1. “I want to lose 20 pounds.” “Dropping 20 pounds is a great long-term goal, but dieters tend to fall off track when they have such a lofty resolution,” says Amidor. Instead: Lose one pound per week.
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Pooled analysis indicated a maximum reduction in BMI of 1.4 kg/m2 in metformin-treated children in studies with durations of 6 http://www.prnewswire.com/news-releases/garcinia-cambogia-extract—crucial-data-released-231403591.html to 12 months, they reported in JAMA Pediatrics. “Given that the mean BMI at our study outset was 33, this reduction was only 3.6% greater than lifestyle interventions (mean change from baseline in these groups was close to zero), less than the 5% to 10% goals often cited as a marker for meaningful weight loss,” the researchers wrote. “Similarly, weight change was 3.77 kg (8.3 pounds) in studies limited to 6 months.” With obesity on the rise among teens and kids, off-label use of metformin to treat childhood obesity has also increased. The drug is currently approved for type 2 diabetes in children aged 10 years and older. To examine the safety and effectiveness of metformin to treat childhood obesity, McDonagh and colleagues performed a systematic review of 14 clinical trials published between 1996 and 2012.
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